Tuesday, March 21, 2006

The Best of Last Over (a book review)

This is something I have never done before. I am thinking outside the box and fishing for new revenue streams. Amazon better realize they have a good thing with me, if they don't pay I'll jump ship!

"The Best of Last" Over by Paul Clipper

I've included a link for more info and pricing.

Every time I read this I am reminded of the time I ambled home from the local pubs and upon walking into my house found it had been ransacked! My phone was on the floor,VCR on the floor stuff was scattered everywhere, my first thought was I had been robbed, but why was my wallet lying on my dinning room table? ( When I walk into the village I like to travel light, a little cash and a strong thirst).
I looked around puzzled and then heard a chirping noise coming from my upstairs, I quickly recognized the chirping as that of a Raccoon.I put two and two together and decided I needed some self defense so I ran down to my basement and found a ski pole I thought would be suitable for corralling a Raccoon out of me casa. I slowly rounded the stairway to my loft and stood staring at three juvenile Raccoon's. I kinda told them to leave and they just looked at me puzzled, I said "scoot get a move on come on get". No movement so then I realized I needed to be more aggressive and I got between them and my stairs and started screaming profanity's and banging the ski pole on my floor, they got the idea and I finally herded the little bastards into my basement. I opened my entry door and persuaded two to leave but the third was jammed tight face forward in between my ceiling joists not ready to be my friend. At this moment of confrontation I heard a little motor sound buzz past my house and I new it was Boz the Village midget and he was riding his 50cc mini bike back from the pubs himself. I was at wits end so I called him and asked him if he knew how to scare a Raccoon out of your house, his reply was simple "you got a gun"? I said thanks remembering what my dad had always advised me, never ask a midget on the sauce for advice. It occurred to me I had scared the Raccoon enough so I just left my basement door to the wilds open and went to bed. In the morning the the little guy was gone and all I had to do was pick up the mess and wipe down all the soot from the chimney they had spread.Its like dude why do I always think of this when I read this book? Read the book, if you like reading and riding then its a good fit also never seek consul from a drunk midget.


At 2:59 PM , Blogger Roscoe said...

Coincidence Abounding:
Josh had raccoon problems.
CrabCake had raccoon problems.
Josh knows Paul Clipper.
Paul Clipper is a motorcycle fanatic.
Clipper knows someone in Sydney.
Jungle Jane lives in Sydney.
Josh knows Boz, a motorcycle midget.
I once found Boz's picture on the Internet.
Jungle Jane probably knows where to find “weird” midget pictures on the Internet.
Go figure.

At 5:52 PM , Blogger josh williams said...

The intro from a letter of a fan.

Josh--Someday, someone is going to come and drive a wooden stake
your heart, I swear to god. I can't fuckin believe that you go out
looking for this stuff!

At 8:31 PM , Blogger jungle jane said...

Roscoe its not just that. the spooky truth is that although i am not a midget i am short. and i ride a motorcycle.

i think we all agree that this is just a little bit more spooky than usual...

At 4:04 AM , Blogger Roscoe said...

I was at Josh Williams’ house when I met Boz - Josh hosted a barbeque. Unaware of any food preparation, I ate a mushroom snack on my way to the mingle. Upon arrival, I handed my car keys to my brother as get-togethers at Josh’s turn into the brannigan. I felt queasy.

Soon the squawk of flying Penguins overwhelmed most conversation, and as I cursed their rudeness, one bird landed next to me and said, “You left your car lights on. Give me your keys and I’ll turn them off.”

“This is Boz.” Josh introduced. “Fat chance Penguin!” I replied loudly.

At 4:52 AM , Blogger josh williams said...

JJ: There is only one thing left to do. Start a cult and become rich.

Roscoe here is the rest of the story I never told you...It was a key exchange swingers party, Boz took you home. You kept calling him "Emporer Penguono", it was a little strange, remember asking me where the child size tuxedo came from that was stuffed under your visor?

At 5:07 AM , Blogger crabcake said...


"Never ask a midget on the sauce for advice?" Oh man, that was priceless.

You have outdone yourself this time, Josh.

At 7:45 AM , Blogger josh williams said...

CC: Thanks, funny but still sound advice.

Roscoe: I was just kiddin' and stuff.

At 6:11 PM , Blogger madman said...

I thought drunk midgets were wise and all knowing

At 8:28 PM , Blogger Captain Carl said...

Arrrr........ay got plenty Of advice, and ay may only be 10inches tall and me breath may smell of rum but...ay not be a pornstar......um......well...arrr...ay...dont drink what tubgirl is servin, now that is sound advice.......

At 4:59 AM , Blogger josh williams said...

MM: That is the common myth, the hard truth is they are not.Never, is a word I seldom use, never seek the consul of a dwarf in his cups.

CC: Arr thems words of a man of the sea. Yer wise beyound your inch's.

At 7:42 AM , Blogger kellywalters said...

I think you need rydlin

At 10:17 AM , Blogger josh williams said...

Roxi: I think Ritalin is over prescribed. However I read a study recently in the Economist about Grapefruit Juice magnifying the affects of opiates up to 4 times more than alcohol! So I think I will just find some sort of opiate based drug and wash it down with grapefruit juice and see if I even out.Thanks for the concern, you good people.

At 6:28 PM , Blogger josh williams said...

Published: March 21, 2006
In 1989, a group of Canadian researchers studying a blood pressure drug were astonished to discover that drinking a glass of grapefruit juice dangerously increased the drug's potency.
They were testing the effects of drinking alcohol on a medicine called Plendil. The scientists needed something that would hide the taste of alcohol so that subjects would know only that they were taking the drug and not know whether they were drinking alcohol with it.
"One Saturday night, my wife and I tested everything in the refrigerator," said David G. Bailey, a research scientist at the London Health Sciences Center in London, Ontario, and the lead author on the study. "The only thing that covered the taste was grapefruit juice."
So they used it in their experiment, expecting the grapefruit juice to be irrelevant to their results. But blood levels of the drug went up significantly in the control group that drank just grapefruit juice, without alcohol.
"People didn't believe us," Dr. Bailey said. "They thought it was a joke. We had trouble getting it published in a major medical journal."
Eventually the paper was accepted and published by Lancet, in February 1991.
Finding why juice had that effect was the next question.
The answer, it turned out, lay in a family of enzymes called the cytochrome P-450 system, in particular one known as CYP 3A4. This enzyme metabolizes many drugs, and toxins as well, into substances that are less potent or more easily excreted or both.
Grapefruit juice interferes with the ability of CYP 3A4 to do that, increasing the potency of a drug by letting more of it enter the bloodstream, in effect producing an excessive dose.
Grapefruit interacts with this enzyme only in the intestines, not in the liver or other places where it is found. As a result, the effect is seen only with medicines taken orally, not with injected drugs.
Numerous studies now show the interaction of grapefruit juice with many widely used medicines. Most interactions have no serious consequences, but a few do. For example, drugs used to lower cholesterol, like Lipitor, Mevacor and Zocor, have increased potency when taken with grapefruit juice. Excessive levels of those drugs can lead to a serious and sometimes fatal muscle disorder called rhabdomyolysis.
Does this mean a person could reduce the amount of medicine required simply by drinking grapefruit juice? No, according to Dr. Bailey.
"The problem is the unpredictability of the effect," he said. "You can't just lower your dose of Lipitor and increase your consumption of grapefruit juice. There's no uniformity from one individual to another or from one bottle of grapefruit juice to the next.
"There's huge variation in the amount of enzyme people have in their guts. Fooling around with grapefruit juice is not a good idea."
Grapefruit juice can also interfere with the metabolism of selective serotonin reuptake inhibitors, or S.S.R.I.'s, like Prozac, which are used to treat depression.
Dr. Marshall Forstein, an associate professor of psychiatry at Harvard, said he told patients to switch from grapefruit juice to something else because most oranges and other citrus fruits do not have the same effect.
"If they insist," Dr. Forstein said, "I try to prescribe the S.S.R.I. or other medication to be taken at a time when the grapefruit juice would have mostly been metabolized."
Among fruit juices, grapefruit has the strongest effect, but lime juice and orange juice made from Seville oranges similarly inhibit the CYP 3A4 enzyme. With some drugs, apple juice may interact in the same way.
While Dr. Bailey suggests avoiding grapefruit juice entirely when taking medicine, some experts say the effect of the juice should not be exaggerated.
"The circumstances under which an interaction will occur are relatively unusual," said Dr. David J. Greenblatt, a professor of pharmacology at Tufts. First, he said, the drug has to be metabolized significantly by intestinal CYP 3A4, and relatively few are. "When you look at the actual data for each drug, the scientific conclusions are that the interactions are unusual, sometimes quite small and not of clinical importance. But there are some cases in which it's significant."
Dr. Greenblatt and his co-investigators at Tufts have conducted research sponsored by the National Institutes of Health in this field for years, and he has been a paid consultant to the Florida Citrus Commission.
Dr. Richard B. Kim, a professor of medicine and pharmacology at Vanderbilt University, agreed that the interaction was a serious health concern in some patients.
"Grapefruit consumption is a clinically relevant issue, especially for the elderly, who are most likely to be taking the drugs affected by it," Dr. Kim said. "If you're taking multiple medications, or have recently switched to a different type of medication, you should be particularly careful. The easiest thing to do under those circumstances is to take the medicine with water and avoid the juice completely."

At 8:17 PM , Blogger jungle jane said...

what do you mean "Just Joking", Josh? you mean i WASN'T supposed to shag Roscoe senseless the night i went home with him, his car keys and Boz?

Jesus Josh. a bit late to be telling me now, huh?

At 5:07 AM , Blogger josh williams said...

JJ: I was trying to protect Roscoes reputation, I know what happened and I was also trying to protect your reputation, even white lies can hurt. I'm not very good at being duplicitous. To both of you, I am deeply ashamed and apologize with all my heart, but then again its not my fault you came to my party, in fact its all you Jane and Roscoes doing trying to make me look bad.Dang I am but a pawn to stoke your egos, well no longer! Kind Regards and forgive me for what ever mental anguish I may have caused you and Roscoe. Secretly I was hoping ya'll would have a love child and there would be little Jungle Roscoes running around our fair planet. I have no idea why Roxi would think I need ritalin?As for the grapefruit juice I read the entire story and found out it affects all sorts of meds so if you are on anti-psychotics you could become as passive as a dog bed, or if you are on ritalin you could become...I dunno. Roscoe told me about your birth mark.

At 3:43 PM , Blogger Le Chitelier said...

I once took a medicine that the pharmacist warned me never to take grapefruit juice with... but that was seventy years ago.

At 11:22 PM , Blogger ing said...

MMMMMMMtired. Grapefruit juice + melatonin = the way to sleep through Josh's snoring.


At 6:56 AM , Blogger josh williams said...

Le: OD like a rock star.

ing: Stop projecting your snores onto me, I do not nor have I ever snored.

At 7:39 AM , Blogger kellywalters said...

that my friend.. is a good idea

At 8:22 AM , Blogger Bloodgood said...

Guns, Raccoons, Midgets, Opiates, and Grapefruit juice, these are a few of my favorite things. Queue Julie Andrews. I think you have all the elements to have a riveting remake of sound of music. We can even throw in Roscoe and Janes love child to be.
Think of the review you could write on that.

At 1:34 PM , Blogger jungle jane said...

Right-ho i have successfully given birth to Roscoe's love child. it came out the womb and asked for a cold beer.

i must say it does look suspiciously like you, Josh.

I am going to name him Mule...

At 2:42 PM , Blogger josh williams said...

Roxi: Why thankee.

Blood: My head spins!

Jane: I'm welling up, Mule is a wonderful name!

At 2:52 PM , Blogger Roscoe said...

A chip off the ol' block. Maybe.

At 5:38 PM , Blogger josh williams said...

Roscoe: You know your Janes babys daddy, so dont try to spin this exchange. I think it would be the right thing to do to admit paternety and sign the boy up for the beer of the day club. A head start aint spoiling the child its just a head start. Cangrats Roscoe you got yourself a love child!A antipode at that...Do the proper thing and fly Jane over to the right side of the world so as to give little Mule a honest start.


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